Abstract

OPPORTUNITIES AND CHALLENGES TO DEVELOP TRANSDERMAL PATCH WITH NANOCARRIER

Pankaj Sharma* and Mukul Tailang

Abstract

The aim of the present study was to review the opportunity and challenges for development of transdermal patch with nanocarrier system. Nanocarriers are colloidal systems, in this particle or droplet size should be smaller than 500 nm. Nanocarriers are non-invasive delivery carriers that enable drugs to reach the hypodermic layer of skin layers and/or the systemic circulation. Effective targeting of drugs can be achieved by using suitable hosting molecules on their surface, which is govern for recognizing and binding to specific receptors on the target molecules. Enhanced delivery of potent drugs through the skin and cellular membranes by means of a nanocarrier opens numerous challenges and opportunities for the research and future development of novel improved therapies. Transdermal patch can be developed by new nanocarriers such as nanoemulsions, vesicular (liposomes, ethosomes etc.), nanoparticles etc. This review article is focused on the potentials of nanocarrier for dermal and transdermal drug delivery.

Keywords: Nanocarrier, Transdermal patch, Vesicular system, Skin.