Abstract

COMPUTER ASSISTED DESIGNING (CADD), IN SILICO PHARMACOLOGICAL AND IN VITRO STUDIES OF A SERIES OF AZOMETHINE DERIVATIVES OF LEADING SEMI SYNTHETIC AMINOPENICILLIN (AMOXICILLIN)

*Abhilash Mullasseril

Abstract

The incorporation of computers and invention of much suitable medicinal chemistry software attracted the interests of many scientists to the field of drug designing and discovery. For an expert drug designing scientist it is necessary to develop his interdisciplinary skills and knowledge to interpret the observations more scientifically to achieve his goal of drug discovery. One of the majour research problems facing recently by the scientists is the enhanced drug resistances shown by common pathogens. It is not easy and economic to develop a specific drug each time to overcome this challenging problem. The easiest possible solution is the derivatization of the presently prescribing drugs at their possible sites by strictly adhering to governing rules like Lipinski rules. In this research paper application of Computer Assisted Drug Designing (CADD), In silico QSAR studies, Synthesis and characterization, systematic antibacterial screening of a series of azomethine derivatives of leadingly prescribing aminopenicillin (amoxicillin) etc. are achieved in a fruitful manner to demonstrate the solution that can be adopted in an economic manner by reducing the time and expenses for drug discovery processes.

Keywords: Computer Assisted Drug Designing (CADD), In silico QSAR Studies, Amoxicillin, Docking, ?-Lactams and ?-Lactamases, Lipinski rules