Abstract

PREPARATION AND BIOLOGICAL STANDARDIZATION OF ANTACID FORMULATION

Joshi Dinbandhu*, Jain Yogita, Malviya Sapna and Kharia Anil

Abstract

Antacids are commonly used self-prescribed medications. It consist of calcium, magnesium and aluminium salts in various combinations. The effect of antacids on the stomach is due to partial neutralization of gastric hydrochloric acid and inhibition of the proteolytic enzyme, pepsin. Herbal antacids are also one of the major classes of over the counter drugs used by patient considering its safety. Hence, in present study we attempted to prepare two formulations, one is aluminium hydroxide suspension and second is combination of calcium carbonate and magnesium oxide suspension as well as compares this by marketed formulation through antacid activity using in vitro methods viz- acid-Neutralizing capacity and buffering capacity. From the results of present study, it may be concluded that our both formulations possess more antacid potential than marketed formulation.

Keywords: Antacid, Suspension, Formulation.