Abstract

COMPARATIVE STUDY OF AQUEOUS FOLIAR EXTRACT OF ANTHOCEPHALUS CADAMBA ON NORMAL AND ALLOXAN INDUCED DIABETIC RATS

Abhishek Kumar*, Basant Kumar and Dr. Garima Bartariya

Abstract

Normoglycemic and hyperglycemic study was performed on albino Wistar rats to evaluate the effect of aqueous foliar extract of Anthocephalus cadamba in normal rats and diabetic rats respectively. For normoglycemic study rats were divided into three groups (one control and two test groups) and each group contains three rats. Group 1 i.e control remained untreated whereas group 2 and group 3 i.e test group were treated with 100mg/kg body weight and 200mg/kg body weight of plant extract respectively. For hyperglycemic study rats were divided into four groups (one control and three test group) and each group contains three rats. Control group was remains untreated whereas test group were treated with 100mg/kg, 200mg/kg body weight of plant extract and 600 μg/kg body weight of metformin respectively. Metformin is a standard drug used to cure diabetes. Hyperglycemia was induced by the oral administration of alloxan monohydrates. Rats with blood glucose level range of 200-300mg/dl were used for the study. Results of normoglycemic study revealed that reduction in blood glucose level was 13.51% and 27.92% respectively after 60 min. The intensity of reduction was continued after 120 and 180 minutes of dosing whereas in case of hyperglycemic study, reduction in blood glucose level was 11.48% at 5th, 20% at 10th and 33.61% at 15th days at a dose of 200mg/kg body weight of Anthocephalus cadamba leaves extract whereas 8.03%, 20.08% and 28.12% at 5th, 10th and 15th days at 100mg/kg body weight of plant extract. Reduction in blood glucose level by Metformin was from 256 to 159mg/dl.

Keywords: Normoglycemia, Hyperglycemia, Anthocephalus cadamba, Metformin, Wistar rat.