Abstract

COMPARATIVE STUDY OF SILDENAFIL CITRATE THERAPY VERSUS LOW DOSE ASPIRIN IN EARLY INTRAUTERINE GROWTH RESTRICTION

*Dr. Gitanjali Bulani, Dr. S. A. Inamdar and Dr. Aprajita Chawla

Abstract

Introduction: A complex and dynamic interaction of maternal, placental and fetal environment is involved in ensuring normal fetal growth. An imbalance or lack of coordination in this complex system may lead to intrauterine growth restriction(IUGR). In India, the prevalence of LBW has been reported as 26%. While the proportion of IUGR has been found to be 54%. Low dose aspirin is one of the most widely used drug for IUGR but sildenafil citrate is emerging drug for IUGR. The aim of study is to compare the effect of sildenafil citrate and low dose aspirin in intrauterine growth restriction. Material and Method: Study was conducted in tertiary care referral unit on 150 patients diagnosed with IUGR and were divided into three groups. Effect of drug was evaluated with improvement in ultrasonography parameter. Result: In present study there was increase in abdominal circumference of more than 10th percentile in 66% patient in sildenafil group, 58% in aspirin group and 38% in control group. Similarly there was increase in fetal weight of more than 10th percentile in 56% in sildenafil group, 50% in aspirin group and 20% in control group Conclusion: More improvement was seen with use of sildenafil citrate as compared to low dose aspirin in IUGR cases.

Keywords: IUGR, Sildenafil citrate, Aspirin.