Abstract

SYNTHESIS OF SUBSTITUTED SULPHONAMIDE DERIVATIVES AND EVALUATION OF THEIR EFFECT ON SPATIAL MEMORY IN ALZHEIMER’S MODELS

Neeraj Masand*, Satya Prakash Gupta and Ratan Lal Khosa

Abstract

Alzheimer’s dementia is a major cause of disability and mortality andthe typical neuropathological hallmarks of Alzheimer’s dementia aredeposition of protein aggregates/ plaques, formation of neurofibrillarytangles and neuronal cell death. Lack of effective anti-AD drugs anddrawbacks of present therapeutic option has helped to design a seriesof N-substituted aryl sulphonamides derivatives (4a-o). All thesuccessfully synthesized compounds were evaluated for the treatmentof dementia models i.e. MWM test. The study confirms ability of N-(2-bromo-4-chloro benzyl) sulphonamide analog with tri-chlorosubstitution (4f) as effective anti-AD drug based on its ability toovercome the deficit during MWM as well as reduced Aβ deposition.

Keywords: Alzheimer’s disease, Morris Water Maze, Aryl sulphonamides, A? deposition.