Abstract

IN VITRO FREE RADICLE SCAVENGING, ANTIDIABETIC AND ANTIBACTERIAL POTENTIAL OF SCHIFF BASE COMPLEXES OF COPPER(II) AND NICKEL(II) DERIVED FROM β-DIKETONE WITH AROMATIC DIAMINE

Syed Tajudeen S.*, Karthik D., Ibrahim Sheriff A. K., Gayathri M., Nidhi Sharon Das, Tamoghna Das and Paridhi Pillai

Abstract

Synthesis of a novel tetradentate β-diketone based ligand, two copper(II) and nickel(II) complexes [CuL2(Bipy)] and [NiL2(Bipy)H2O] is describe here. The complexes were synthesized by simple reaction of copper(II) and nickel(II) metal salts with tetradentate β-diketone based ligand under the solvothermal conditions and characterized by several techniques such as elemental analyses, molar conductivity measurements, magnetic moments, spectral (UVVis, FT-IR, 1H NMR,13C NMR) techniques. The catecholase activity of the copper(II) and nickel(II) complexes were carried out using pyrocatechol as the substrate. Among the two complexes the copper(II) catalyst exhibited remarkable activity. The synthesized ligand and complexes were also screened for their anti oxidant, in vitro antidiabatic and in vitro anitbacterical activity studies.

Keywords: ?-diketone, aromatic diamine, catecholase activity, anti oxidant, in vitro antidiabatic activity, in vitro anitbacterical activity.