Abstract

THE EFFECT OF ORAL DOMPERIDONE ON QTC INTERVAL IN INFANTS AND CHILDREN

Abd El Mohsen A.*, Antonios M. A. and El Makhzangy H. I.

Abstract

Domperidone is commonly used in pediatrics, it is accused to be one of the causes of long QT syndrome which can lead to death. Lot of studies have been done to evaluate its cardiac safety. The aim of this study was to evaluate the effect of domperidone on QT interval, this study is a prospective case control study which was done on 100 patients aged from 3 months to 5 years coming to Alexandria University Children's hospital, 50 cases received domperidone for 7 days or more while other 50 cases did not. Electrocardiogram was done to all patients and QTc interval was measured using Bazett’s formula. The results showed that 8% of cases showed prolongation of QTc interval ≥ 0.45 ms, after one week of domperidone stoppage, QTc interval normalized. Overall, this study showed no statistically significant difference in QTc duration induced by domperidone. However, domperidone cardiac safety cannot be ensured.

Keywords: Domperidone, Long QT Syndrome, Arrhythmia, Pediatric.