Abstract

DESIGN AND EVALUATION OF MOXIFLOXACIN PERIODONTAL FILMS

G.Velrajan* P.Sambasivarao ,S.Kannan 

Abstract

Moxifloxacin is a broad spectrum antimicrobial agent, which is formulated into films and evaluated for the treatment of periodontitis. Chitosan films containing moxifloxacin in three different concentrations (5%,10% and 15% w/w to the weight of polymer), MBL- 25%, MTL-25% were prepared by the solvent casting technique, using 1%v/v acetic acid solution. The prepared films were evaluated for various properties such as weight variation, tensile strength, stability studies, in-vitro release and moisture loss studies. Average weight and thickness among the different films was uniform. Tensile strength was minimum for single layer and maximum for bilayer and trilayer films. The stability studies did not show any significant changes. Static dissolution studies showed a burst release initially followed by a progressive fall in the release of the drug.

Keywords: Chitosan, Moxifloxacin, Periodontitis, Films.