Abstract

FAST DISSOLVING TABLETS: AN OVERVIEW

Mahesh Kumar Kataria*, Smaily Jain and Ajay Bilandi

Abstract

Oral route is considered as safe and prefect route for administration of drug. Fast dissolving / disintegrating tablets are innovative approach for the patients who have difficulty in swelling the tablets and liquids. Traditional tablets and capsules are administered with an 8-oz. glass of water may be inconvenient or impractical for some geriatric and paediatric patients. Such problem can be solved in the novel drug delivery system by formulating ―mouth dissolving tablets‖ (MDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of super-disintegrant or maximizing pore structure in the formulation. Fast dissolving tablets dissolve or disintegrate rapidly in oral cavity without intake of water. On comparison with conventional dosage form FDT have several advantages. This review describes the various formulation aspects, benefits, limitations, patented and non patented technologies developed for MDTs, marketed formulation and drugs used in this research area.

Keywords: Mouth Dissolving Tablets, Orally Disintegrating Tablets, Super-disintegrates, Bioavailability and Fast-Dissolving/Disintegrating Tablet (FDDTs).