Abstract

EVALUATION OF PROTECTIVE EFFECT OF POLYHERBAL FORMULATION ON STREPTOZOTOCIN AND HIGH FAT DIET INDUCED HYPERLIPIDAMIEA, ATHEROSCLEROSIS AND SEXUAL DYSFUNCTION IN DIABETIC RATS

MD. Faheemuddin*, Dr. Pankaj Kumar Sharma, Dr. N. Siva Subramanian, Prof. Dr. Birendra Shrivastava

Abstract

Introduction: Diabetes is the metabolic disorder with multi aetiologies’ characterized by chronic hyperglycaemia which is leads to many other disorders. Diabetic complications like cardiovascular disorders, renal failure, hepatic disorders, diabetic foot and many other disorders. (Josephine M. et al 2011). In the present study Ethanolic extract of Verbascum Thapsus, Lotus corniculatus Carlina acaulis were used to prepare poly herbal formulation and it was evaluated for the antiatherosclerosis, antihyperlipidamic and sexual potency in high fat diet and Streptozotocin induced diabetic activity. Methods: Animals weight of 120-140grams were selected and Diabetes was induced to the animals using Streptozotocin and provided with high fat diet to induce atherosclerosis, hyperlipidamiea and sexual dysfunction. After the inducing of diabetes blood glucose levels and lipid profile was determined which is considered as 0th day and treatment was given till 45day. On the 45th day all the blood and tissue pathological studies were carried out. The PHF toxicity studies were carried out and dose of 100 mg/kg and 200mg/kg body was given during the 45 days study period. For reference standard glibinclamide drug treated, toxic control and normal group was also used. Results: From the biochemical parameters and histopatological studies it was proved that the PHF is effective in controlling blood glucose levels, lipid profile along with sexual potency in male rats. It was having more significant value than that of standard drug to maintain the sexual potency in male rats.

Keywords: Poly Herbal Formulation, Ethanolic extract, Glibinclamide, Streptozotocin, Vitamin D3.