Abstract

ENHANCEMENT OF DISSOLUTION RATE OF ACECLOFENAC USING HYDROPHILIC CARRIERS BY SOLID DISPERSION TECHNIQUE

Sutha P.* and Sangameswaran B.

Abstract

The main objective of this study was to investigate the effect of various hydrophilic carriers on the dissolution behavior of aceclofenac. Solid dispersion was prepared using Poly Vinyl Pyrrolidone (PVP), Mannitol or Urea as hydrophilic carriers by kneading and physical mixing methods. The micromeritic properties, Fourier transform infra-red (FTIR) spectroscopy, percentage practical yield, drug content, wettability and in vitro drug releasewere evaluated. The Solid dispersion was prepared in 1:1, 1:3 and 1: 5 weight ratios of the drug to carrier. FTIR studies showed that there was no interaction between the drug and carrier. In vitro release profiles of all Solid dispersions (F1 to F18) were comparatively evaluated and also compred with pure Aceclofenac. Among the Solid dispersions, F15 (1:5) using PVP showed minimal wetting time of 13 seconds and maximum drug release of 93% compared with the other formulations. So, the solid dispersion containing PVP (1:5) by kneading method my offer suitable formulation because of its faster drug release among all formulations and low wetting time. The development of solid dispersion of Aceclofenac could be a promising approach to enhance its dissolution rate and wetability property, which may subsequently minimize the variation in its bioavailability.

Keywords: Solid dispersion, Aceclofenac, Kneading method, Polyvinyl pyrrolidone, Mannitol, Urea.