Abstract

FORMULATION AND EVALUATION OF ANTI-DANDRUFF HERBAL SHAMPOO CONTAINING DATURA METEL [LINN] LOADED SOLID LIPID NANOPARTICLES

Thaifa S. K.* and Arun Kumar K. V.

Abstract

The aim of this present work was to develop anti-dandruff herbal shampoo containing Datura metel Linn loaded solid lipid nanoparticles. Dandruff is a chronic scalp condition characterized by scaling, itching, and redness of the scalp. Yeast like fungus Malassezia furfur was responsible for dandruff formation. Datura metel is a wellknown medicinal plant due to its herbicidal, insecticidal, anti-fungal, anti-bacterial, anti-inflammatory and anti-rheumatoid activity. The leaves of Hibiscus rosa-sinesis also added into this herbal shampoo due to its greater conditioning effect on hair. The Datura metel loaded Solid Lipid Nanoparticles (SLNs) were prepared by high shear hot homogenization followed by ultrasonication method. The organoleptic evaluations of the formulations showed good results. The pH of the shampoo ranged between 5.47 to 6.10, which was near to the skin pH. The percentage solid content of prepared shampoos was found between 22.15-25.30 %. All the shampoos produced stable foams in distilled water with good conditioning performance which was due to the presence of Hibiscus rosa-sinesis leaf extracts. Viscosity and surface tension of developed formulations was found to be 7782.67-8867.87 cps and 30.54-33.16 dynes/cm respectively. All the developed formulations showed anti-fungal activity against Malassezia furfur but F3 produced a better zone of inhibition (32 mm) which was near to the zone of inhibition produced by standard Ketoconazole shampoo (36 mm). The optimized formulation F3 was found to be stable during the period of stability studies. Hence it was concluded that the formulated anti-dandruff herbal shampoo was safe and effective for controlling dandruff with a better conditioning effect.

Keywords: Dandruff; Malassezia furfur; Datura metel Linn; Hibiscus rosa-sinesis Linn; Solid Lipid Nanoparticles (SLNs); Herbal anti-dandruff shampoo.