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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

DESIGN AND SYNTHESIS OF NOVEL HYDROXY â€“ ANTHRAQUINONE DERIVATIVES AS ANTI-LESHMANIAL AGENTS

Ubbani Ramakrishna* Alle Swathi, Sujatha Banavath, R. Suthakaran, Yelugudhari Ramulu, Ragya Eslavath and Goli Venkateshwarlu

Abstract

To synthesized the novel series of hydroxy anthraquinones derivatives using Friedel-Crafts acylation reaction and were identified as potential antileishmanial chemotype. Among the synthesized eight analogues, 2 analogues (7f & 7g) exhibited better antileishmanial chemotype. Among the synthesized 8 analogues, 2 analogues (7f & 7g) exhibited better antileishmanial activity against intracellular amastigotes form of Leishmania donovani. The compounds were also non-toxic towards Vero cells. Compounds 7a, 7b and 7h also have significant in vitro activity (IC50 values of

Keywords: Antileishmanial activity, 13C NMR and 1H NMR Spectra, characterization.

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