Abstract

FORMULATION AND INVITRO EVALUATION OF BIOADHESIVE BILAYERED BUCCAL TABLETS OF ENALAPRIL MALEATE

Vineela Sangu* and H. Padmalatha

Abstract

In the present study bilayer buccal tablets were formulated by using ethyl cellulose as backing membrane. From the foregoing investigation it may be conclude that the release rate of drug from the buccal tablets can be governed by the polymer and concentration of the polymer employed in the preparation of tablets. Regulated drug release in first order manner attained in the current study indicates that the hydrophilic matrix tablets of enalapril maleate was prepared using carbopol 934 and HPMC K100 can successfully be employed as a buccoadhesive controlled released during delivery system. The pre compression blend for all formulations was subjected to various evaluation parameters and the results were found to be within limits. The post compression parameters for all the formulations also found to be within limits. Slow, controlled and complete release of enalapril maleate over a period of 9 hours was obtained from matrix tablets formulated employing HPMC K 100 (F5 Formulation) with 93.45 % drug release.

Keywords: Bilayer buccal tablet, Enalapril maleate, HPMC, Carbopol.