Abstract

PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF OFLOXACIN

N. Saritha* and Dr. S. Jaya

Abstract

The aim of the study was to develop and physico-chemically characterized solid dispersions of Ofloxacin by using hydrophilic polymers. Ofloxacin is quinolone derivate used for the treatment of fungal infection. Ofloxacin is belongs to the category of poorly water soluble drug. For this drug, dissolution is the rate determining step. We have to increase the solubility of the drug by preparing the solid dispersions. Ofloxacin is an appropriate model drug for formulation of solid dispersions forms due to its poor solubility it is a BCS class II drug, which affects its solubility. Therefore development of solid dispersions of ofloxacin can be advantageous that can provide increase efficacy. In the present study solid dispersions of ofloxacin were prepared by physical mixture method. Prepared dispersions were studied for drug polymer compatibility, characterized for powder blend properties and in vitro drug release studies. Different types of polymers were used poloxomer PEG and Urea were used for the preparation of solid dispersions of ofloxacin. The in vitro release profile of solid dispersions of ofloxacin suggests that formulation containing polaxomer (F8) which consisted of the drug: polymer ratio of 1:1 showed satisfactory drug release 98% at the end of 45 minutes among all formulations.

Keywords: ofloxacin, solid dispersions, polymer, poloxomer, in vitro, compatability.