Abstract

CHRONOLOGICAL EFFECTS OF ANTIHYPERTENSIVES IN A TERTIARY CARE HOSPITAL

Mangu Pranav*, Kainat Panjwani, Sandhya Vinjamoori and Dr. Manjari Bodasu

Abstract

Hypertension has been a major public health issue and is common among all the ages indeed. In coming years frequency is expected to be increase considerably. According to International Society of Hypertension (ISH) patients with hypertension will progress to cross 1.56 billion by 2025! chronobiology has important effects on a drug's action. Blood pressure (BP) follows a circadian rhythm, with BP levels falling during sleep and increasing in the early morning hours in most individuals. The current prospective study is based on the chronological effects of morning Vs bed time administration of the most commonly prescribed antihypertensives in a tertiary care hospital and which is beneficial. Chronotherapeutics is the purposeful alteration of drug level to match rhythms to optimize therapeutic outcomes and minimize size effects. A sample size of 178 patients has been chosen from the study site limiting to the inclusion criteria precisely. Majorly the drugs chosen for this study were ARBs, calcium channel blockers and beta blockers which are most commonly used in any tertiary care hospital. Among the three classes of drugs calcium channel blockers showed a significant difference from the baseline when administered in the morning than evening, the remaining classes which were taken into consideration did not show any significant differences from baseline blood pressure. This experimental study gives us the potential drug administration and knowing the effective therapeutic potency of the drugs. On the other hand, physicians and practitioners all over the world should guide the public regarding the high or low blood pressure may be the major signs that many other body organs are in high risk. The message conveyed should be in such a way it should make every individual think regarding the unhealthy lifestyle consequences.

Keywords: Chronobiology, circadian rhythm, drug administration, chronotherapuetics, chronological effects.