Abstract

IMPACT OF AGGLOMERATIVE PHASE OF COMMINUTION (APOC) ON PERFORMANCE CHARACTERISTICS OF UNCOATED TABLET

RajveerBhaskar, Monika Ola, ManojPatil*

Abstract

Agglomerative phase of comminution is a relatively newer granulation cum particle size reduction technique in which agglomeration of the fine coherent particle take place into loose granular structure. Agglomeration of the fine cohesive particles produced during grinding particularly with rotating or oscillating ball mills. Reduction of particle size during prolonged grinding by a ball mill has been used as a novel means of producing a pharmaceutical granulation. When compared with conventional granulation methods, this method produced mechanically stronger tablets with a higher dissolution rate than those compacted from granules made by a conventional wet granulation method. A possible mechanism for the increased dissolution rate is the increased internal surface area of the particles produced by the prolonged grinding method. Increased homogeneity and bioavailability characteristics can be obtained both by help of this granulation technique.

Keywords: Agglomeration, granulation, particle size, bioavailability, dissolution, ball mill.