Abstract

THE ANTIMICROBIAL ACTIVITY OF PARGULARIA DAEMIA LEAVES EXTRACT AGAINST BACTERIAL PATHOGENS ISOLATED URINARY TRACT INFECTIONS

Dr. P. Suganthi*

Abstract

The leaves of Pargularia daemia belonging to family Asclepiadaceae was investigated to evaluate in vitro antimicrobial activity of methanolic extract against urinary tract infection causing pathogens consisting of Staphylococcus aereus, Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Candida albicans, and Aspergillus niger. The major Urinary Tract Infection (UTI) causing bacterial and fungal pathogens under investigation were tested by the disc diffusion assay method and the minimum inhibitory concentration was evaluated. Methanolic extract exhibited a significant and broader spectrum of inhibition followed by petroleum ether, aqueous and chloroform extract against bacterial pathogens. The results of antifungal activity revealed that Pargularia daemia extract inhibited fungal pathogens significantly with a broader spectrum of inhibition. An attempt has been made to compare the activity of extract with most potent standard antibiotics (Baccteria -ciprofloxacin (25 μg/disc; Fungi - clotrimazole (10 μg/disc) effective against selected UTI causing pathogens under test.

Keywords: Urinary Tract Infection, Antimicrobial activity, Antibiotics, Pargularia daemia.