Abstract

ASSOCIATION ASSESSMENT OF THROMBOPHILIC GENE MUTATIONS IN KASHMIRI WOMEN WITH RECURRENT MISCARRIAGES

Syed Shafia, Mahrukh H. Zargar*, Rehana Ahmad and Nabeela Khan

Abstract

Aim: To access the prevalence of factor V Leiden and prothrombin G20210A mutations in Kashmiri women with recurrent miscarriage in comparison to control group of parous women. Method: FVL and prothrombin G20210A mutations were analysed in 100 women with RM in comparison to 100 parous women. The mutations were analysed using ARMS- PCR approach. Result: All the recurrent miscarriage cases and controls were found to have FVL GG genotype and prothrombin 20210 GG genotype. There was no association of these mutations with the development of recurrent miscarriage. Conclusion: We conclude that FVL and prothrombin G20210A mutations do not contribute to the pathophysiology of recurrent miscarriage in Kashmiri women. Therefore, its screening is not indicated as an initial approach in Kashmiri women with RM.

Keywords: Factor V Leiden; Prothrombin G20210A; Recurrent miscarriage; Kashmir.