Abstract

FORMULATION AND EVALUATION OF VALACYCLOVIR MUCOADHESIVE MICROSPHERE

Sahoo P.K.*, Dinda S.C., Kanungo S.K.

Abstract

Valacyclovir microspheres were prepared by ionic gelation technique. The process induced the formation of microcapsules with the incorporation efficiency of 70% to 90%. The effect of HPMC, CMC (Mucoadhesive polymer) & sodium alginate concentration and conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristics and in vitro release behaviours. Infrared spectroscopic study confirmed the absence of any drug ‐ polymer interaction. Microcapsules matrices showing spherical surface, which was confirmed by scanning electron microscopy study. The mean particle size and entrapment efficiency were found to be varied by changing various formulation parameters. The in vitro release profile could be altered significantly by changing various formulation parameters to give a sustained release of drug from the microcapsules.

Keywords: Valacyclovir hydrochloride, Microspheres, HPMC, Sodium alginate, CMC & Drug release.