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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF TRANSITION METAL COMPLEXES OF THIOSEMICARBAZONE BEARING VANILLIN MOIETY

Javed G. Mahetar, Mayank J. Mamtora, Mitesh B. Gondaliya, Rohit B.Manawar,Manish K. Shah*

Abstract

The synthesis and spectral analysis of Cu(II), Ni(II),Co(II) and Zn(II) complexes of 3-Chloro Vanillin Thiosemicarbazone (3-CVTSC) is reported. Their characterization using mass spectroscopy, elemental analysis, 1H NMR, 13C NMR, infrared spectroscopy,UV spectroscopy and Thermal Gravimetric Analysis as well as their antimicrobial properties were evaluated. In the formation of metal complexation, the metal is coordinated through the azomethine nitrogen and covalently to the sulfur atom.

Keywords: Synthesis, Thiosemicarbazone, Metal Complexes, Antimicrobial Activity.

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