Abstract

EVALUATION OF HAIR GROWTH ACTIVITY OF HIBISCUS ROSASINENSIS AND CALOTROPIS GIGANTEA LEAVES ON STRESS INDUCED ALOPECIA

*Dr. Namrata Singh, Dr. Mukul Tailang and Dr. Anupam K. Pathak

Abstract

In the present hair growth study, the various parameters like hair length, hair density, total serum protein, testosterone, total leucocytes count and histology were performed in stress induced alopecia albino rat model. It can be affirmed that 5% ointment of hydrolcholic leaves extract of Hibiscus rosa-sinensis, Calotropis gigantea and Polyherbal formulation of H. rosa-sinensis + C. gigantea showed reflective results. From the observations it was concluded that H. rosa-sinensis show significant hair growth as compare to C. gigantea and Polyherbal formulation of H.rosa-sinensis + C. gigantea. In this model exposure to sonic stress inhibits the growth of a hair shaft producing (anagen) hair follicle by premature induction of hair follicle regression (catagen) and up-regulated keratinocyte apoptosis. Against the stress not any herbal preparation were formulated, but these results indicate that Hibiscus rosa-sinensis, Calotropis gigantea and their polyherbal formulation promoting hair growth activity. Further study will be carrying out to find out chemical active constituents of these plants which promoted hair growth.

Keywords: Hibiscus rosa-sinensis, Calotropis gigantea, sonic stress, Cyclophosphamide, Alopecia, Histopathology.