Abstract

LIPOIDAL NANOPARTICULATE DRUG DELIVERY OF OFLOXACIN FOR OCULAR USE

Nida Parveen* and Dr. Sobhna Singh

Abstract

The aim of the present study was focused on the development of solid lipid nanoparticles based gelling system of an antibiotic drug to be administered through ocular route. Four formulations (F1, F2, F3 & F4) of solid lipid nanoparticles were prepared containing ofloxacin. Solid lipid nanoparticles were prepared by emulsification followed by sonication method. Prepared ofloxacin containing solid lipid nanoparticles were evaluated for particle size, shape, surface morphology, drug content and in-vitro drug release studies. The average particle size was found to be in range 354.2 nm, the particles were uniform, spherical in shape and had 70 to 88.3%w/w of drug entrapped in it. The drug release from solid lipid nanoparticles showed sustained release of drug. All the formulation showed better result in terms of stability. Among the four formulations the best result were found with F4 formulation of ofloxacin. The solid lipid nanoparticles of ofloxacin were incorporated in gel so as to make it suitable to be administered by ocular route. Solid lipid nanoparticles containing gel showed drug delivery up to 92.73%. Ofloxacin nanoparticles loaded gel showed better result when compared with the ofloxacin nanoparticles; because the release rate revealed that the gel gave higher release of drug initially for quick onset of action.

Keywords: Solid lipid Nanoparticle (SLN), Gelling system, Ofloxacin, Ocular Route.