Abstract

INVESTIGATION OF ANTI-UROLITHIATIC ACTIVITY OF LINUM USITATISSIMUMAND MIMOSA PUDICA IN EXPERIMENTALLY INDUCED UROLITHIASIS IN ANIMAL MODELS

*R. Naga Kishore

Abstract

Objectives: The present study was undertaken to evaluate the effects of some traditional medicinal plants i.e., Linum usitatissimum and Mimosa pudica in combination and in alone on experimentally-induced (urolithiasis) kidney stones. Methods: Urolithiasis in animals was induced experimentally by administration of ethylene glycol (0.75% v/v) with ammonium chloride (1% w/v) in drinking water for ten days. The aqueous extract of both plants were administered alone and in combination to urolithiasis induced test group rats at a dose of 400 mg/kg respectively for 10 days. After 10 days, renal function parameters measured such as increase in the urine urea, uric acid, and calcium and creatinine levels, which reflect the deposition of calcium oxalate in the kidneys. Results: The serum analysis showed significant increase in the serum uric acid, serum creatinine, blood urea and calcium in urolithiasis control group rats. In addition, vehicle treated induction control group rats showed significant increase in the biochemical parameters. Conclusion: Daily oral treatment with all most all extracts not significantly decreased the quantity of calcium oxalate deposited in the kidneys but also reverted all the biochemical changes induced by calcium oxalate urolithiasis thus supporting its traditional claim. Aqueous extract of both plants in combination and in alone was found to be significant when compared with standard and control group.

Keywords: Urolithiasis, Creatinine, Mimosa pudica, Linum usitatissimum.