Abstract

ANTIULCEROGENIC ACTIVITY OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA BARK IN WISTAR ALBINO RATS

Ch. Anunya*, Vivek Tiwari, Dr. P. Veresh Babu and Dr. M. Gangaraju

Abstract

The present study was under taken to evaluate Antiulcer activity of Ethanolic bark extract of Moringa oleifera against ethanol and acetic acid induced ulcer models. Ethanol is widely used ulcerogenic agent which induces acute gastric ulcers, ethanol induced ulcers which is associated with significant production of o2 free radicals leading to lipid peroxidation with consequent damage to cell and cell membrane. Moringa oleifera significantly protects the gastric mucosa against the ethanol challenge, as shown by the reduced values of ulcer index. The extract had shown dose dependent significant effect when compared to ethanol control group. Acetic acid induced chronic ulcer model is another classical model for evaluation of antiulcerogenic activity. Exposure to glacial acetic acid produces deep penetrating gastric ulcers with clear vascular injury, edema, hemorrhagic streaks, epithelial thickening and necrotic lesions. The bark extract of the plant had shown pronounced dose dependent protective effect evident by reduced ulcer index. The activity of the extract was found to be significant compared to acetiacid control group in which there was enhanced ulcer index and perforations. The histopathology examination was carried out to determine effect of extracts. These were selected to reflect rate and healing of ulcers. The parameters suggested that the pre-treated rats with ethanolic extract of Moringa oleifera bark (200 mg/kg) or Omeprazole (20 mg/kg) orally significantly reduced the formation of gastric ulcer.

Keywords: Moringa oleifera, Omeprazole, ethanol, acetic acid.