World Journal of Pharmaceutical Research (WJPR) has indexed with various reputed international bodies like :

WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.453

ICV : 90.8

WJPR Citation

	All	Since 2020
Citation	8502	4519
h-index	30	23
i10-index	227	96

User Name :

Password :

Forgot Your Password? | Register

Best Article Awards

World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Track Your Article

Abstract

OXAZINO [2, 3-A] ISOQUINOLINES: POTENTIAL DENGUE VIRUS PROTEASE INHIBITORS IN SILICO APPROACH

Prasanna B. Ranade, Dinesh N. Navale, Santosh W. Zote and M. M. V. Ramana*

Abstract

Dengue, a viral disease presently having neither effective antiviral chemotherapy nor approved vaccine. Therefore, designing new scaffolds against dengue virus replication is an important aspect for researchers. Tetracyclic compounds were known to exhibit antidengue activity. Hence we perform the docking studies on designed tetracyclic derivative, oxazino [2, 3-a] isoquinolines against dengue virus NS2B/NS3 protease. The hydrogen bonding, hydrophobic interactions and Van der Waals forces between designed compounds with Lys74, Trp83, and Leu149 amino acid residues of the NS2B/NS3 protease is also discussed.

Keywords: Oxazino [2, 3-a] isoquinolines, Dengue Virus Protease, Docking, ADME prediction.

[Full Text Article] [Download Certificate]