Abstract

SYNTHESIS, CHARACTERIZATION, ANTI MICROBIAL AND ANTIOXIDANT ACTIVITY OF CHALCONES FROM 3-METHOXY ACETOPHENONE

P. S. Raghu*

Abstract

Chalcones were important starting materials for the synthesis of various classes of five, six and seven member heterocyclic compounds. In the present work Chalcones were synthesized by base catalysed Claisen–Schmidt condensation, of 3-mehoxy acetophenone with appropriate aldehydes followed by dehydration. Six Chalcones were synthesized and structures were confirmed by spectral evidence. The compounds were tested for anti microbial activity and antioxidant activity using diffusion method by measuring the Zone of the inhibition and DPPH measuring by measuring the percentage of inhibition. In that compound B3 shows potent activity than compare with other compoundswith Staphylococcus aureus zone of inhibition 16, 22 mm at 500 μg/ml, 1mg/ml, with Pseudomonas aeruginosa zone of inhibition 14, 22 mm at 500 μg/ml, 1mg/ml, with Escherichia coli the zone of inhibition 14, 26 mm at 500 μg/ml, 1mg/ml. compounds B3 shows potent activity than other compounds at concentration of 51. 24± 0.27 μM.

Keywords: Chalcones, Claisen–Schmidt condensation, anti microbial, anti oxidant, DPPH Reagent.