Abstract

LIFAGO DIELSII SCHWEINF AND MUSCHL (ASTERACEAE) AMELIORATES LIVER INJURY INDUCED BY ISONIAZID AND RIFAMPICIN IN RAT

Samiya Baali, Hanane Aïssaoui, Ahmed Menad, Ratiba Mekkiou, Nacera Baali, Fadila Benayache and Souad Ameddah*

Abstract

The Lifago dielsii has been used in Algerian folk medicine for the treatment of various disorders since ancient time. In this study we aimed to investigate the possible hepatoprotective effects of n-BuOH extract of Lifago dielsii (BELD) in isoniazid (INH) and rifampicin (RIF)-induced liver injury model. Administration of INH and RIF for 14 days resulted in hepatic failure as evidenced by the elevation of aspartate aminotransferase (AST), alanine aminotransaminase (ALT), and hepatique oxidative stress which was associated with extensive hepatic parenchyma alteration. The co-treatment of rat with BELD (200 mg/kg; 14 days) attenuated the increase of hepatic dysfunction markers (AST, ALT) and suppressed malondialdehyde (MDA). BELD co-treatment restored GSH level and reversed the antioxidant parameter SOD as compared to the quercetin co-treatment in suppressing MDA level and in GSH, SOD levels preservation. The histopathological protection was clearly confirmed by the reduction of hepatic alteration. Conclusion: The data obtained in the present study revealed that Lifago dielsii butanolic extract has significant hepatoprotective activity against INH and RIF-liver injury that may be attributed to its bioactive constituents.

Keywords: Lifago dielsii, Isoniazid, Rifampicin, oxidative stress, liver injury.