Abstract

EVALUATION OF PHARMACOLOGICAL PROFILE OF KOJU®- A NIGERIAN POLYHERBAL FORMULATION, IN WISTAR RATS

Idakwoji Precious Adejoh* and Uzuazokaro Mark- Maria Agatemor

Abstract

Polyherbal formulations are mixtures of many plant parts obtained from various plant species and families. These plant combinations usually contain a wide array of bioactive compounds making them suitable for the treatment and management of a variety of disease conditions. These formulations are prepared most often and dispensed by individuals without formal training. As a result, experimental screening method is important in order to ascertain the efficacy and safety of these herbal products. This study investigated the pharmacological profile of Koju® (KPF) - a common Nigerian polyherbal formulation developed from Xylopia aethiopica (root bark), Securidaca longepedunculata (stem bark), Magnifera indica (stem bark), Allium sativum (seed), Citrus aurantifolia (root bark), Morinda lucida (seed) and Saccharum officinarum. The pharmacological profile was evaluated via investigation of its anti-hyperglycaemic potential (using alloxan- induced diabetes rat model), anti- bacterial potential (using in vitro action against bacterial isolates), anti- malarial potential (using P. berghei berghei inoculated mice model), analgesic potentials (using hot plate method), anti- inflammatory potential (using egg albumin- induced paw oedema model) and anti- pyretic (using bakers’ yeast induced hyperpyrexia model). Results showed that KPF reduced hyperglycaemia in rats, Inhibited salmonella spp isolate in vitro and P. berghei berghei in mice and exhibited analgesic and inflammatory effect in rats. It was concluded that anti-hyperglycaemic, anti- bacterial, anti- malarial, analgesic and anti- inflammatory activities are part of the pharmacological profile of Koju polyherbal formulation.

Keywords: Pharmacological, Koju®, Polyherbal, Formulation.