Abstract

SPECTROPHOTOMETRIC DETERMINATION OF HALOPERIDOL WITH 2,3 DICHLORO 5,6 DICYANO – 1,4 BENZOQUINONE

Mallapu E. Rani*

Abstract

We present the validation of a developed a new spectro photometric method on a charge transfer complexation reaction. In this method, the reaction of Haloperidol with 2,3 dichloro 5,6 dicyano 1,4 benzo quinone (DDQ) in chloroform mixture to form an light orange colour charge transfer complex. The light orange colour solution was stable for more than 24 hrs and was used to determine the haloperidol spectrophotometrically. The absorbance of the light orange colour solution was measured at 470 nm, against the reagent blank Beer’s Law was obeyed for 50-250 μg/ml of haloperidol. Results of analysis were validated statistically evaluated. The procedures described were successfully applied to the determination of haloperidol in tablets.

Keywords: DDQ Method by spectrophotomethically, Haloperidol Method of validation.