Abstract

TEST METHODS OF BIOADHESIVE SYSTEM

Prajapati Twinkle Kantibhai*, Kaushika S. Patel and Dr. Shreeraj Shah

Abstract

The term bioadhesion commonly defined as adhesion between two materials where at least one of the materials is of biological origin. In the case of bioadhesive drug delivery system. Bioadhesion often refers to the adhesive between the excipients and biological tissue. Application of dosage forms to mucosal surfaces may be of benefits to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive, materials, factor affecting mucoadhesion, evaluating methods and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).

Keywords: Bioadhesion, tensile strength, retention time, adhesion number, mucosa.