Abstract

CURRENT APPROACHES IN THE TREATMENT OF OSTEOSARCOMAS

Akhilesh Mishra, Gayatri Dewangan*, Ramdas Singh, Amartya De,Jui Chakraborty and T.K. Mandal

Abstract

Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. In most cases, typical radiographic features clearly illustrate the aggressive bone forming nature of the lesion. The successful treatment of patients with osteosarcoma requires close co-operation within an experienced multidisciplinary team including pediadric or medical oncologists, surgeons, physicians, pathologist and radiologists. Therapy must include complete surgical removal of all detectable tumor sites as well as multi-agent chemotherapy. Novel approaches are needed in order to improve their prognosis and developing to new targeted drug delivery techniques for less toxicity to the host. In this article we discuss clinical presentation, diagnosis, different types of treatment, health promotion and physico-chemical care for patients with osteosarcoma

Keywords: Chemotherapy, osteosarcoma, methotrexate, radiotherapy, targeted drug delivery