Abstract

EFFECT OF COCCINIA INDICA EXTRACT FRUIT AND LEAF ON DIABETIC NEUROPATHY PAIN IN RATS

Somnath Kharwar*, Prof. (Dr.) B. B. Panigrahi, Md. Quammudin, Balwan Singh and Khalid Iqbal

Abstract

We investigated the effect of freshly prepared chloroform extract ofcocciniaindica fruit and leaf extracton neuropathic pain, blood glucoselevel and loss of body weight in hyperglycaemic rats. Streptozotocin(STZ; 60 mg/kg, IP) was injected to albino rats to induce diabetes. Oraladministration of freshly prepared chloroform extracts to each of theanimal was given to STZ-induced diabetic rats until 7 weeks after theSTZ injection at a dosage of 500 mg/kg/day and 250 mg/kg/day Theglucose level test to follow the changes in blood glucose and bodyweight measurement to evaluate loss of body weight in diabetic rats.The pain evaluated by stimuli thermal: warm immersion (52+2) andcold immersion test (100C) and paw withdrawal on Eddy’s hot plate(45-52 +2) in diabetics rats. Treatment with these freshly prepared fruit and leaf chloroformextract significantly reduced blood glucose and pain in diabetic rats. Blood glucose loweringeffect and analgesic activity of cocciniaindica decreased the pain in STZ- diabetic rats. STZinducedloss of body weight was attenuated by the chloroform extract of the cocciniaindica.The higher dose (500 mg/kg/day) of chloroform extract of the cocciniaindica therapy workbetter than that of lower dose (250 mg/kg/day) against hyperglycaemia and painfulneutopathy in STZ-induced diabetes rats. Therefore the use of these plants as analgesic andantidiabetic is justified. The rosiglitazone (10 mg/kg/day) also knows as thiazolidinediones isan antidiabetic drug. In other member class of medication known as pioglitazone. It is used asa standard drug and maintains the glucose level and diabetic neuropathic pain in diabetic rats.

Keywords: Cocciniaindica, rosiglitazone, analgesic, hyperglyceamia,body weight, STZ-induced diabetic rats.