Abstract

UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF ROSIGLITAZONE MALEATE IN PHARMACEUTICAL DOSAGE FORMS

Snigdharani Behera*, Sujit Kumar Martha and Pratit Kanchan Sahu

Abstract

The objective of the proposed method is to develop simple & accurate method for the determination of Rosiglitazone maleate by UV spectrophotometric method in pharmaceutical dosage forms. Stock solution of Rosiglitazone was prepared & the calibration curve was drawn by suitable dilution of the standard solution. Commercially available Rosiglitazone tablet was taken & analysed. And the validation of the adopted method was ascertained by Precision & Accuracy. From the studies, it was found that, Rosiglitazone obeys linearity within the concentration range of 1-80μg/ml. From the results of precision study, it was found that the % R.S.D is less than 2%, which indicates that the method has good reproducibility. From the results of accuracy study, it was found that the % recovery values of pure drug from the pre-analysed solution of formulation were in between 97.5-98.12%, which indicates that the proposed method is accurate. The proposed method is specific while estimating the commercial formulations without interference of excipients and other additives.

Keywords: Rosiglitazone, Methanol, Precision, Accuracy, Validation.