Abstract

A NOVEL APPROACH TO THE SYNTHESIS OF FLORFENICOL

Gaddam Prabhakar, Dasari Raju, Kadari Sudhakar & B.M.Choudary*

Abstract

The article describes a convenient and ecofriendly synthetic route for the synthesis of florfenicol from readily available thiamphenicol 1 by using inexpensive and recyclable solid catalysts. The strategy is based on the preparation of cyclized alcoholic oxazolidin-2-one 3. This compound was protected with mesityl chloride in DCM and added Cu- HAP as a catalyst than followed by fluorinated with KF/PEG and added HAP as a catalyst to form fluorinated oxazolidin-2-one 5. This compound was opened up by reaction with sulfuric acid in dioxane and later the amino group was dichloroacetylated with methyldichloroacetate by copper hydrotalcite (Cu-HT-2) in DCM to obtained florfenicol 7 with good yield. All the synthesized compounds were established by their spectral and elemental analysis.

Keywords: Thiamphenicol, florfenicol, hydrotalcite, hydroxy apatite, Cu-hydrotalcite