Abstract

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF NOVELLY SUBSTITUTED ALIPHATIC AMIDES CONTAINING PYRIMIDINE NUCLEUS AS ANTIBACTERIAL AND ANTHELMINTIC AGENTS

Hareesh S. R.*, Venkatalakshmi V., Manoj Kumar K. E., P. K. Kalleshappa, Dayananda K. S.

Abstract

The paper presents the synthesis of some new amides containing pyrimidine as core moiety 6a-e by the reaction between acid 4 with different substituted amines in the presence of base. The key intermediate 4 was synthesized from compound 1 via Suzuki coupling and then hydrolysis reaction. The structures of compounds were confirmed by IR, 1H NMR, 13C NMR and CHN elemental analysis. The newly synthesized compounds were evaluated for their antibacterial activity. It was found that few amides exhibited significant antibacterial activity.

Keywords: Suzuki coupling, pyrimidine, dikis, cesium carbonate, 3-(3-dimethylaminopropyl) carbodiimide hydrochloride, hydroxybenzotriazole, antibacterial activity.