Abstract

ANTIBACTERIAL AND ANTICANCER ACTIVITY OF GREEN SYNTHESISED TITANIUM DIOXIDE NANOPARTICLE FROM TERMINALIA CHEBULA

Renuka M. and Dr. Soundhari C.*

Abstract

Objectives: To synthesize titanium nanoparticles from Terminalia and compare the antibacterial and anticancer effectiveness of biologically synthesized titanium nanoparticles to crude extracts. Methods: Green synthesis of titanium dioxide nanoparticles (NP) is carried out with the fruit rind extract of Terminalia chebula The NP was characterized by FTIR and SEM. Antibacterial activity of the NP was checked against clinical pathogens. The antioxidant activity was determined by DPPH assay. Cytotoxic activity was done on vero cell lines and toxic free concentrations were estimated. Anti cancer activity was done against A549 cell lines by MTT assay. Results: Titanium nanoparticles were biologically synthesized. The particles showed antibacterial activity and exhibited antioxidant nature higher than the extracts. Cytotoxicity assay revealed the nanoparticles were nontoxic and were capable of inhibiting proliferation of A549 cell lines. Conclusions: T. chebula was found to be a good source for biosynthesis of titanium nanoparticles which exhibited significant activity than the extract. Hence its concluded that nanoparticles are more suitable for drugs than crude extracts.

Keywords: Green synthesised nanoparticles, Titanium dioxide, Terminalia chebula, DPPH, MTT assay.