Abstract

NANOEMULSION: A WAY TO ENHANCE BIOAVAILABILITY

Wasim Khan*, Dr. Zeashan Hussain and Noor Fatima Siddique

Abstract

Poor water solubility is still the main problem for the formulator which can be overcome by nanonization to larger extent which in turn increase drug loading and enhanced bioavailability. Nanoemulsions have attracted great attention in research, dosage form design and pharmacotherapy .Nanoemulsions are composed of oil droplets dispersed in an aqueous medium and stabilized by surfactant molecules. Nanoemulsion is a heterogeneous system composed of one immiscible liquid dispersed as droplets within another liquid. The droplets size of nano emulsion is between 20 to 500 nm. Diameter and surface properties of droplets of nanoemulsion plays an important role in the biological behavior of the formulation. Small droplet sizes lead to transparent emulsions so that product appearance is not altered by the addition of an oil phase. The methods used for the production of nanoemulsions include HPH, microfluidization, ultrasonication and spontaneous emulsification. Nanoemulsions have widespread applications in different fields such as pharmaceutics, food technology and cosmetics. In this paper various aspects of nanoemulsion have been discussed including advantages, limitations and methods of preparation.

Keywords: Microfluidization, nanoemulsion, droplet, surfactant, immiscible.