Abstract

DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL BILAYERED TABLETS OF METOPROLOL SUCCINATE

A. Anka Rao*, Dr. C. H. Babu Rao and Dr. N. Devanna

Abstract

The purpose of this research work was to establish mucoadhesive buccal tablets of Metoprolol succinate in the forms of bilayered tablets. The tablets were prepared using Hydroxy propyl methyl cellulose (HPMC K100M) and Poloxamer 407 as a bio adhesive polymers to impart Mucoadhesion and ethyl cellulose (EC) to act as an impermeable backing layer. Buccal tablets were evaluated by different parameters such as weight variation, content uniformity, thickness, hardness, surface pH, swelling index, ex vivo mucoadhesive strength, in vitro drug release, and in vivo studies. The mechanism of drug release was found to be non-Fickian diffusion (value of n between 0.5 and 1.0) for both the buccal tablets. The present study concludes that mucoadhesive buccal tablets of Metoprolol succinate can be a good way to bypass the extensive hepatic first-pass metabolism and to improve the bioavailability of Metoprolol succinate.

Keywords: Bilayered buccal tablet, buccal delivery, Mucoadhesion, Metoprolol succinate.