Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2, 4- THIAZOLIDINEDIONES AS ANTIDIABETIC AGENTS

Ramesh L. Sawant and Sonali T. Gade*

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. At least 90% of all cases are accounts for type II diabetes mellitus. All new series of 2, 4 thiazolidinediones derivatives were synthesized by conventional as well as microwave irradiation method. The structures of these compounds were established by IR, H1 NMR and elemental analysis. All these compounds (3a-3j) were screened for antidiabetic and antihyperlipidemic activity on albino rats. Most of these compounds shown significant activity when compared with standard drug Pioglitazone.

Keywords: Thiazolidinediones, conventional method, microwave irradiation, pioglitazone.