Abstract

FORMULATION AND IN-VITRO CHARACTERISATION OF MICROCAPSULE OF LOSARTAN FOR ORAL DELIVERY

A. K. Rath*, S. K. Martha and P. K. Sahu

Abstract

Sustain release drug can be formulated by modifying dosage form into microcapsule, which provide facilities of maintaining better bioavailability, control release characteristics and provide protection of drug from environment thus increasing the stability of drug. Losartan is a drug in the market with Angiotensin II antagonist action, used for treatment of hypertension. It has the longest half life as well as longer duration of action with respect to any drug in this class for eg. Losartan.in the present study losartan microcapsules were formulated by using eudragid, HPMC, sodium alginate, etc as additives. Further various characteristics like micrometretic, dissolution, bioavailability were studied. As per the experimental work, the microencapsulated form of losartan was found to overcome poor solubility and poor permeability characteristics.

Keywords: Losartan, Microcapsule, Eudragid, Sodium Alginate, Hpmc.