Abstract

FORMULATION AND EVALUATION OF TOPICAL CREAM OF PIPERINE FOR VITILIGO

P. Satyendra, P. Arun, P. Shailendra, *D. Neelesh and K. Neeraj

Abstract

The main interest of the investigations gathered here was in pursuit of developing a topical dosage form of a suitable antivitiligo agent. In the light of reported works on antivitiligo activity of piperine, this project was aimed to bring a ray of hope to the “down casted” by a dosage form incorporated with the bioactive compound piperine, as the API (active pharmaceutical ingredient) for antivitiligo. The formulation must be able to achieve the drug to penetrate the stratum corneum and get lodged in the dermal layers without further trespassing into the systemic circulation. Thus the tissue bioavailability of the drug in the dermal region must be maximized where the melanocytes proliferency and formation of melanocytic dendrites can be achieved. The formulation and development of conventional topical preparations-cream and ointment incorporated with piperineis also carried out with a NDDS known as phytosomes.

Keywords: Piperine, Vitiligo, Ointment, Phytosme, Creams.