Abstract

FORMULATION AND EVALUATION OF NAIL DELIVERY SYSTEMS OF VORICONAZOLE

Vaishali Potnis*, Suchita Dhamane, Jyoti Kute, Rameshwar Tidke and
Suneeti Gore

Abstract

Novel nail lacquer formulations of Voriconazole (1%w/w), a second generation triazole derivative, were prepared for topical treatment of onychomycosis. The plasticized nail lacquers were prepared using nitrocellulose (RR Type) and ethyl cellulose as film formers in organic solvent system using purified papain (5%w/w) and DMSO (3%w/w) as penetration enhancers. Both the placebo and drug loaded nail lacquers were characterized for clarity, viscosity (cps), specific gravity, non-volatile content , and uniformity of coat, smoothness, gloss, water resistance and drying time of applied lacquer Moreover, the medicated lacquers were characterized for transungual permeation (in- vitro), drug content, antifungal efficacy against T. rubrum (MTCC No.296) and C. albicans (NCIM No.3471).The formulation based on nitrocellulose and containing purified papain indicated good clarity, low viscosity (375-400 cps), faster drying (65-70 sec) and formed glossy, smooth films with more than 99% of VCONZ that indicated diffusion over a period of 6 hrs and remained stable with no gross change in any of the physicochemical characteristics and antifungal efficacy.

Keywords: Onychomycosis, Antifungal treatment, Penetration enhancer, Medicated nail lacquers.