Abstract

EVALUATION OF ANTIEPILEPTIC ACTIVITY OF ETHANOLIC EXTRACT OF POPULUS DELTOIDES LEAF IN MICE

Kalbant Kumar*, Pankaj Kumar Shankhdhar and Ratandeep Chauhan

Abstract

Populus deltoides leaf commonly known as eastern cottonwood belongs to the Salicaceae family. In the present study, Ethanolic extract of Populus deltoides leaf (EEPL) was tested for anticonvulsant activity in albino mice, using different convulsive models. The Ethanolic extract of Populus deltoides leaf produced significant anticonvulsant activity in all models studied. The present study also revealed that EEPL increase the concentration of nor-adrenaline and dopamine in brain of mice which attributed to the significant protection against MES induced seizures. Significant results were observed in the estimated parameters thereby justifying the use of this medicinal plant in the treatment of epilepsy.

Keywords: Epilepsy, Populus deltoides, maximal electroshock, pentylenetetrazole, strychnine, seizures, Nor-adrenaline, Dopamine.