Abstract

ELECTRICAL CONDUCTANCE, SURFACE TENSION AND ACOUSTICAL PROPERTIES OF AQUEOUS SOLUTIONS OF {CETYLTRIMETHYLAMMONIUM BROMIDE + METOCLOPRAMIDE HYDROCHLORIDE DRUG} AT 30OC

B. D. Ridhorkar, A. D. Arsule* and R. T. Sawale

Abstract

It is very interesting to study the micellization of cationic surfactant like cetyltrimethylammonium bromide (CTAB) in presence of electrolyte drug in aqueous solution. Therefore, here we report the effect of antiemetic metoclopramide hydrochloride monohydrate (MCH) drug on various experimental properties like density (), electrical conductance (), surface tension (), and ultrasonic velocity of CTAB in aqueous drug solutions at 30oC. The cmc of CTAB was determined from electrical conductance and surface tension and compared. Various acoustical parameters like adiabatic compressibility ( ), specific acoustic impedance (Z) and relative association (RA) showed nonlinear variation with CTAB concentration. Reduction in the cmc value of CTAB in presence of electrolyte drug has been observed.

Keywords: Adiabatic compressibility, Conductance, Drug-surfactant interactions, Surface tension.