Abstract

DESIGN AND EVALUATION OF POLYMERIC FILMS (HPMC) OF ENALAPRIL MALEATE FOR TRANSDERMAL USE

Hemantkumar Bhosale*, Pooja Bansude, Vishal Babar and Prajwala Khapale

Abstract

Objective: The aim of the present investigation was to develop medicated and non-medicated transdermal films. Methods: Nonmedicated films were formulated with different ratios of polymers HPMC K4M and K100M glycerol as a plasticizer, whereas the medicated films were formulated of antihypertensive agent Enalapril maleate using same polymers and plasticizer. The possible drugpolymer interactions and compatibility were studied by FTIR and DSC studies. Results: Formulated transdermal films were formulated for various physicochemical characterization, in-vitro diffusion study, stability studies and in-vitro diffusion data was analyzed by using various kinetic models. The results of all physicochemical parameters were found to be within limits. The in-vitro diffusion study was performed using Franz diffusion cell and full thickness rat abdominal skin as a barrier. The in-vitro diffusion data revealed that JK4 formulation batch showed good permeation at the end of 10hrs. Conclusion: The physicochemical characterization and permeability studies indicate that the drug & polymers is suitable for Transdermal drug delivery.

Keywords: Transdermal films, HPMC K4M, HPMC K100M, glycerol, Enalapril maleate.