Abstract

CYTOTOXICITY OF MAYTENUS EMARGINATA (WILLD) ON BREAST CANCER CELL LINES BT474

Dhanasree Basipogu*, Syed Nizamuddin Basha and Suresh Kumar Chitta

Abstract

Maytenus emarginata is an indispensable remedial plant known as "Danthi" in Ayurveda and for the most part used for the treatment of flu, fever, irritation and even the gastric ulcers. In folk medicine it is utilized for antitumor action. The purpose of our present study is to evaluate the cytotoxic activity of Maytenus emarginata isolates against the Human Breast development cell lines BT474. The Cytotoxic activity was assessed by MTT test and % block of cells was found out. The results have shown that 30 mg/ml of Methanol concentrate of leaves of the plant exhibited the moderate cytotoxic activity (57 %) against BT474 cell line with IC50 15.4 ± 0.3. Hereafter it develops the way that M. emarginata (leaves) has cytotoxic action against human breast tumor (BT474) cell lines.

Keywords: Maytenus emarginata, Cytotoxic, MTT and BT 474.