Abstract

REVIEW ON APPROCHES OF ORAL GASTRO RETENTIVE DRUG DELIVERY SYSTEM

M. Swetha*, B. Mohan, G. Natesh and Sushma

Abstract

The purpose of this review on Oral gastro retentive drug delivery systems (OGRRDDS) was to compile the recent literature with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Gastro retentive drug delivery system belongs to oral controlled drug delivery system group that are capable to retain in the stomach by passing the gastric transit. These dosage forms are also defined as floating drug delivery system, which can float in the contents of the stomach and release the drug in a controlled manner for prolonged periods of time. This review was summarized important factors controlling gastric retention. Afterwards, we have written various gastro retentive approaches designed and developed until now, i.e. Floating systems it is again divided into Effervescent and non-effervescent system (Hydro dynamically balanced system, Microporous compartmental systems, alginate beads, Hollow Microspheres), Swelling and expanding system, Bio-adhesive systems, Highdensity systems, Modified-shape systems, and evaluation of Gastro-Retentive Dosage Form.

Keywords: OGRRDDS, Floating systems, Effervescent, non-effervescent system, Hydro dynamically balanced system, Microporous compartmental systems, alginate beads, Hollow Microspheres, Swelling and expanding system, Bio-adhesive systems, High- density systems, Modifi