Abstract

FORMULATION AND DEVELOPMENT OF IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF QUINAPRIL

Nagaraju D.*, Taher Patel and Dr. N Siva Subramanian

Abstract

The present investigation was to develop and evaluate floating drug delivery system of an angiotensin-converting enzyme (ACE) inhibitor class of medications (Quinapril). The floating tablets of Quinapril were prepared by using HPMC K4M, HPMC E15LV, Carbopol 940 polymers. The tablets were prepared by direct compression method. Dissolution measurements were carried out in a (USP) dissolution testing apparatus II. The compatibility study of was performed by FTIR for the prepared Quinapril floating tablets confirms that there is no interaction between the drug and polymers used. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms. The drug release kinetics was observed by Non-fickian diffusion mechanism and was concluded that the formulation with HPMC E15 LV shows better sustained release effect. The developed floating tablets of Quinapril may be used to prolong drug release for at least 12h, thereby improving the bioavaibility and patient compliance.

Keywords: Quinapril, HPMC E15 LV.